Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses
نویسندگان
چکیده
منابع مشابه
Nanoparticle–Cell Interactions: Molecular Structure of the Protein Corona and Cellular Outcomes
The use of nanoparticles (NPs) in biology and medicine requires a molecular-level understanding of how NPs interact with cells in a physiological environment. A critical difference between well-controlled in vitro experiments and in vivo applications is the presence of a complex mixture of extracellular proteins. It has been established that extracellular serum proteins present in blood will ad...
متن کاملInduction of Allergic Responses to Peanut Allergen in Sheep
Peanut allergy is the leading cause of deaths due to food-induced anaphylaxis but despite continued research, there are currently no specific treatments available. Challenge testing is limited in patients due to the high risk of adverse reactions, emphasising the need for an appropriate animal model. In the present study we examine the induction of allergic responses in a sheep model for peanut...
متن کاملThe protein-nanoparticle interaction (protein corona) and its importance on the therapeutic application of nanoparticles
Nanobiotechnology has provided promising novel diagnostic and therapeutic strategies which capable to create a broad spectrum of nano-based imaging agents and medicines for human administrations. Several studies have demonstrated that the surface of nanomaterials is immediately coated with suspended proteins after contact with plasma or other biological fluids to form protein corona-nanoparticl...
متن کاملProtein source and choice of anticoagulant decisively affect nanoparticle protein corona and cellular uptake.
Protein adsorption on nanoparticles has been a focus of the field of nanocarrier research in the past few years and more and more papers are dealing with increasingly detailed lists of proteins adsorbed to a plethora of nanocarriers. While there is an urgent need to understand the influence of this protein corona on nanocarriers' interactions with cells the strong impact of the protein source o...
متن کاملNonlinear Responses and Optical Limiting Behavior of Ag Nanoparticle Suspension
In this study, the nonlinear optical properties and optical limiting performance of the silver nanoparticles (AgNPs) in distilled water are investigated. The nonlinear absorption coefficient of the colloid is measured by the Z-scan technique. The optical limiting behavior of the AgNP suspension is investigated under exposure to nanosecond laser pulses at 532 nm. The results show that nonlinear ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Particle and Fibre Toxicology
سال: 2015
ISSN: 1743-8977
DOI: 10.1186/s12989-016-0113-0